Protein desumoylation

Across TCGA cell cohorts, RNA activity of the Protein desumoylation pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HINT1, PFDN1, and RBM12, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein desumoylation activity versus HINT1 in LUNG_NSCLC_LUSC (Pearson r = 0.89).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HINT1 →	+4.619	+1.702	<.001	.003	3	18
URINARY_TRACT	PFDN1 →	+3.063	+2.151	<.001	<.001	3	15
URINARY_TRACT	RBM12 →	+2.000	+2.151	.001	<.001	3	14
URINARY_TRACT	PSMA6 →	+2.135	+2.193	.003	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	PSMB6 →	+1.807	+1.436	<.001	<.001	3	14
OVARY	UBXN1 →	+1.864	+0.656	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016926 vs HINT1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →