Protein sumoylation

Across TCGA patient cohorts, RNA activity of the Protein sumoylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB3D, EPS8L2, and MAP1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein sumoylation activity versus RAB3D in HNSC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RAB3D →	-0.590	-0.080	<.001	<.001	3	6
HNSC	EPS8L2 →	-0.427	-0.063	<.001	<.001	3	6
LSCC	MAP1B →	+0.739	+0.040	<.001	<.001	3	6
LSCC	MAP1B_S1298 →	+0.884	+0.041	<.001	<.001	3	6
LUAD	GALE →	-0.443	-0.033	<.001	<.001	3	5
OV	SLIRP →	-0.463	-0.046	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016925 vs RAB3D — HNSC

Explore this scatter interactively →