Protein sumoylation

Across TCGA patient cohorts, RNA activity of the Protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXM1, PHF8, and PCNX3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein sumoylation activity versus FOXM1 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXM1 →	+0.823	+0.218	.005	.001	3	5
LSCC	PHF8 →	+0.497	+0.177	<.001	<.001	3	5
UCEC	PCNX3 →	+0.438	+0.159	.008	.004	3	5
UCEC	PRRC2A →	+0.438	+0.182	.002	<.001	3	5
LSCC	FBL →	+0.790	+0.227	<.001	<.001	3	5
UCEC	SMARCC2 →	+0.417	+0.186	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016925 vs FOXM1 — BRCA

Explore this scatter interactively →