Protein sumoylation

Across TCGA cell cohorts, RNA activity of the Protein sumoylation pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUMO1, SAE1, and RPS21, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein sumoylation activity versus SUMO1 in SOFT_TISSUE (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SUMO1 →	+1.115	+0.235	<.001	.006	3	17
URINARY_TRACT	SAE1 →	+2.428	+0.464	<.001	<.001	3	16
URINARY_TRACT	RPS21 →	+2.645	+0.606	<.001	<.001	3	16
URINARY_TRACT	RPS28 →	+2.190	+0.506	<.001	<.001	3	16
LARGE_INTESTINE	PCNP →	+1.509	+0.288	.001	.001	3	15
OESOPHAGUS	TPI1 →	+1.883	+0.328	.008	.004	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016925 vs SUMO1 — SOFT_TISSUE

Explore this scatter interactively →