Rac protein signal transduction

Across TCGA patient cohorts, RNA activity of the Rac protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YME1L1, DPYSL3, and C1orf198, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rac protein signal transduction activity versus YME1L1 in BRCA (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	YME1L1 →	-0.303	-0.027	.001	.009	3	8
PDAC	DPYSL3 →	+0.448	+0.033	<.001	.002	3	8
GBM	C1orf198 →	+0.449	+0.054	.008	.001	3	7
BRCA	EIF4B_S93 →	-0.715	-0.026	<.001	.001	3	7
OV	GRPEL1 →	-0.461	-0.040	.001	.002	3	7
LUAD	RPL26 →	-0.425	-0.039	.002	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016601 vs YME1L1 — BRCA

Explore this scatter interactively →