Rac protein signal transduction

Across TCGA patient cohorts, RNA activity of the Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF2C, LINC01936, and CX3CR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rac protein signal transduction activity versus KIF2C in GBM (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIF2C →	-0.831	-0.163	<.001	.001	3	7
LSCC	LINC01936 →	+0.484	+0.143	<.001	.001	3	5
BRCA	CX3CR1 →	+1.696	+0.324	<.001	.003	3	5
BRCA	CPED1 →	+0.853	+0.411	<.001	<.001	2	5
BRCA	JHY →	+0.369	+0.368	.009	<.001	3	4
GBM	EVI2A →	+0.724	+0.211	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016601 vs KIF2C — GBM

Explore this scatter interactively →