Rac protein signal transduction

Across TCGA cell cohorts, RNA activity of the Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPUL1, FARP1, and AGO1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rac protein signal transduction activity versus HNRNPUL1 in LARGE_INTESTINE (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HNRNPUL1 →	+0.729	+0.087	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	FARP1 →	+1.927	+0.096	<.001	<.001	3	13
URINARY_TRACT	AGO1 →	+1.003	+0.098	.001	<.001	3	12
URINARY_TRACT	MAST2 →	+1.194	+0.098	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	ABI2 →	+1.145	+0.088	.002	.008	3	12
LIVER	CIT →	+0.881	+0.070	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016601 vs HNRNPUL1 — LARGE_INTESTINE

Explore this scatter interactively →