Rac protein signal transduction

Across TCGA cell cohorts, RNA activity of the Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF185, RPL7, and CERCAM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Rac protein signal transduction activity versus ZNF185 in BONE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF185 →	+2.474	+1.408	.006	.003	3	5
BREAST	RPL7 →	-0.949	-1.190	.005	<.001	3	4
LUNG_NSCLC_LUAD	CERCAM →	+0.994	+0.630	.004	.004	3	4
SOFT_TISSUE	TNC →	+6.315	+1.357	<.001	.005	3	4
OVARY	DDX49 →	-0.876	-0.968	<.001	.004	3	4
LUNG_NSCLC_LUSC	C1GALT1 →	+1.867	+1.896	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016601 vs ZNF185 — BONE

Explore this scatter interactively →