"Protein import into peroxisome matrix, receptor recycling"

Across TCGA patient cohorts, RNA activity of the "Protein import into peroxisome matrix, receptor recycling" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH5A1, SMYD5, and C5AR1_S327, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Protein import into peroxisome matrix, receptor recycling" activity versus ALDH5A1 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALDH5A1 →	+0.636	+0.059	<.001	.003	3	7
UCEC	SMYD5 →	+0.164	+0.057	.002	.001	3	6
UCEC	C5AR1_S327 →	-0.904	-0.083	<.001	<.001	3	6
LSCC	LTB4R_S320 →	-1.113	-0.058	<.001	<.001	3	6
BRCA	TKFC →	+0.346	+0.040	<.001	<.001	3	6
HNSC	SND1_S645 →	-0.562	-0.075	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016562 vs ALDH5A1 — GBM

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