"Protein import into peroxisome matrix, receptor recycling"

Across TCGA patient cohorts, RNA activity of the "Protein import into peroxisome matrix, receptor recycling" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTLC1P5, LINC02320, and PSG5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Protein import into peroxisome matrix, receptor recycling" activity versus SPTLC1P5 in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPTLC1P5 →	+0.352	+0.317	.002	.001	3	3
GBM	LINC02320 →	+0.397	+0.129	.004	.002	3	3
BRCA	PSG5 →	-0.114	-0.445	<.001	.009	3	3
PDAC	SDHCP2 →	+0.317	+0.890	.002	<.001	3	2
COAD	CTSLP1 →	+0.094	+0.654	.007	.006	2	3
CCRCC	YWHAZP3 →	-0.165	-0.390	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016562 vs SPTLC1P5 — HNSC

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