"Protein import into peroxisome matrix, receptor recycling"

Across TCGA cell cohorts, RNA activity of the "Protein import into peroxisome matrix, receptor recycling" pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INAFM2, LRRK1, and ZNF593, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INAFM2 grouped by "Protein import into peroxisome matrix, receptor recycling"-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	INAFM2 →	-1.428	-1.304	.001	.005	3	5
OVARY	LRRK1 →	-1.721	-1.183	<.001	.003	3	5
LIVER	ZNF593 →	+0.510	+1.472	.001	<.001	3	4
LUNG_SCLC	MPG →	-1.529	-1.719	<.001	<.001	3	4
LUNG_SCLC	CYP4V2 →	-2.059	-1.400	<.001	.001	3	4
LUNG_NSCLC_LUAD	SLC35E1 →	-0.585	-1.047	.008	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INAFM2 by "Protein import into peroxisome matrix, receptor recycling" activity — KIDNEY

Explore this box plot interactively →