"Protein import into peroxisome matrix, receptor recycling"

Across TCGA cell cohorts, RNA activity of the "Protein import into peroxisome matrix, receptor recycling" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C6orf89, KLHL3, and SECISBP2L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Protein import into peroxisome matrix, receptor recycling" activity versus C6orf89 in LIVER (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	C6orf89 →	+0.818	+0.465	<.001	.003	3	4
CNS	KLHL3 →	-0.953	-0.430	.008	.004	3	4
SKIN	SECISBP2L →	-0.896	-0.218	.002	.007	3	4
BLOOD_Lymphoma	YIPF3 →	-0.753	-0.356	.004	<.001	3	4
SKIN	P3H4 →	-1.017	-0.278	<.001	<.001	3	4
OVARY	PLCXD2 →	-3.183	-0.569	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016562 vs C6orf89 — LIVER

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