Peroxisome fission

Across TCGA patient cohorts, RNA activity of the Peroxisome fission pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TYMP, HK3, and UBASH3B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome fission activity versus TYMP in LSCC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TYMP →	-0.501	-0.079	<.001	<.001	3	7
COAD	HK3 →	-0.487	-0.033	.001	.004	3	7
HNSC	UBASH3B →	-0.376	-0.084	<.001	<.001	3	6
GBM	AGFG2 →	+0.408	+0.042	<.001	<.001	3	6
LSCC	MICAL1 →	-0.303	-0.052	<.001	.001	3	6
LUAD	RNASE3 →	-0.617	-0.049	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016559 vs TYMP — LSCC

Explore this scatter interactively →