Peroxisome fission

Across TCGA patient cohorts, RNA activity of the Peroxisome fission pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKAPD1, CUL3, and EIF4A1P10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome fission activity versus NKAPD1 in LUAD (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NKAPD1 →	-0.234	-0.154	.004	.007	3	4
LSCC	CUL3 →	+0.372	+0.197	<.001	.001	3	4
OV	EIF4A1P10 →	+1.400	+0.289	.001	.003	3	4
UCEC	SYDE1 →	-0.664	-0.211	<.001	<.001	3	4
UCEC	EMCN →	-0.897	-0.230	.002	<.001	3	4
UCEC	RPUSD4 →	-0.756	-0.152	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016559 vs NKAPD1 — LUAD

Explore this scatter interactively →