Peroxisome fission

Across TCGA cell cohorts, RNA activity of the Peroxisome fission pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX11B, ACOX1, and ACOT8, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome fission activity versus PEX11B in LUNG_NSCLC_LUAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PEX11B →	+0.760	+0.076	<.001	.002	3	14
BREAST	ACOX1 →	+1.514	+0.210	<.001	<.001	3	13
OVARY	ACOT8 →	+0.630	+0.086	<.001	<.001	3	9
LUNG_NSCLC_LUAD	APH1A →	+0.744	+0.118	<.001	<.001	3	8
BREAST	LIMK2 →	+1.511	+0.151	<.001	<.001	3	8
KIDNEY	TEN1 →	+0.825	+0.105	.003	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016559 vs PEX11B — LUNG_NSCLC_LUAD

Explore this scatter interactively →