Peroxisome fission

Across TCGA cell cohorts, RNA activity of the Peroxisome fission pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNFT1, ADGRG1, and SLC25A13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome fission activity versus RNFT1 in SKIN (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNFT1 →	+0.770	+0.186	<.001	<.001	3	5
SOFT_TISSUE	ADGRG1 →	+3.484	+0.175	<.001	.002	3	5
LUNG_NSCLC_LUAD	SLC25A13 →	+0.711	+0.217	<.001	<.001	3	4
OVARY	CELF4 →	+1.230	+0.312	.002	<.001	3	4
SKIN	CARD14 →	+1.027	+0.159	.003	<.001	3	4
SKIN	TBCD →	+0.810	+0.185	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016559 vs RNFT1 — SKIN

Explore this scatter interactively →