Protein import into peroxisome matrix

Across TCGA patient cohorts, RNA activity of the Protein import into peroxisome matrix pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF19, DCLRE1B, and TAF12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import into peroxisome matrix activity versus TCF19 in CCRCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TCF19 →	+0.494	+0.489	.002	<.001	3	4
LUAD	DCLRE1B →	+0.291	+0.553	.001	.003	3	3
LUAD	TAF12 →	+0.194	+0.499	.007	.008	3	3
UCEC	TRIM36 →	+0.773	+0.720	.004	.001	3	3
UCEC	RCC2 →	+0.432	+0.618	.002	.008	3	3
LUAD	TRNAU1AP →	+0.317	+0.726	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016558 vs TCF19 — CCRCC

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