Protein import into peroxisome matrix

Across TCGA cell cohorts, RNA activity of the Protein import into peroxisome matrix pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2CD2, FAM20C, and C6orf89, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C2CD2 grouped by Protein import into peroxisome matrix-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C2CD2 →	-0.941	-0.649	.002	.002	3	4
LUNG_NSCLC_LUAD	FAM20C →	-1.991	-0.675	.002	.001	3	4
LUNG_NSCLC_LUSC	C6orf89 →	-1.016	-1.546	<.001	.005	3	4
BLOOD_Leukemia	PLEKHG1 →	+1.111	+0.977	.006	.002	3	4
KIDNEY	CNPY3 →	-0.818	-1.007	.007	.007	3	4
LARGE_INTESTINE	GNE →	-1.134	-0.655	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C2CD2 by Protein import into peroxisome matrix activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →