mRNA modification

Across TCGA patient cohorts, RNA activity of the mRNA modification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DUT, TLR2, and ANXA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA modification activity versus DUT in LSCC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DUT →	+0.394	+0.052	.001	.001	3	6
LUAD	TLR2 →	-0.373	-0.039	.001	.003	3	6
LSCC	ANXA2 →	-0.344	-0.038	<.001	<.001	3	6
UCEC	KMT2D_S3130 →	+0.548	+0.078	<.001	<.001	3	5
LSCC	SMC1A →	+0.203	+0.040	<.001	<.001	3	5
LSCC	RPA1 →	+0.253	+0.046	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016556 vs DUT — LSCC

Explore this scatter interactively →