mRNA modification

Across TCGA patient cohorts, RNA activity of the mRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCPG1, PRIM1, and LMOD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA modification activity versus CCPG1 in COAD (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CCPG1 →	-0.362	-0.248	.003	<.001	3	7
LUAD	PRIM1 →	+0.478	+0.178	<.001	.009	3	7
PDAC	LMOD1 →	-0.611	-0.199	<.001	.003	3	7
OV	DCN →	-1.400	-0.175	.004	.003	3	6
COAD	EFEMP1 →	-0.887	-0.164	<.001	.009	3	6
COAD	NEXN →	-0.685	-0.182	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016556 vs CCPG1 — COAD

Explore this scatter interactively →