mRNA modification

Across TCGA cell cohorts, RNA activity of the mRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHNYN, PANK1, and DARS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KHNYN grouped by mRNA modification-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KHNYN →	+0.904	+0.237	.001	.003	3	4
PANCREAS	PANK1 →	-0.580	-0.426	.004	.005	3	3
URINARY_TRACT	DARS2 →	-1.057	-0.559	.003	.002	3	3
URINARY_TRACT	ZNF563 →	+1.045	+0.536	.001	.001	3	3
URINARY_TRACT	ZNF69 →	+2.374	+0.629	<.001	<.001	3	3
LUNG_SCLC	ZMYND8 →	-0.686	-0.375	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KHNYN by mRNA modification activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →