Cytidine to uridine editing

Across TCGA patient cohorts, RNA activity of the Cytidine to uridine editing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DTX3L, IFI35, and NMI, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytidine to uridine editing activity versus DTX3L in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DTX3L →	+0.585	+0.069	<.001	<.001	3	9
HNSC	IFI35 →	+0.511	+0.075	<.001	<.001	3	9
HNSC	NMI →	+0.490	+0.081	<.001	<.001	3	9
BRCA	GBP1 →	+0.854	+0.073	<.001	<.001	3	9
BRCA	UBE2L6 →	+0.765	+0.068	<.001	<.001	3	8
OV	STAT1 →	+0.658	+0.062	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016554 vs DTX3L — OV

Explore this scatter interactively →