Cytidine to uridine editing

Across TCGA cell cohorts, RNA activity of the Cytidine to uridine editing pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMX2, GPSM1, and NUDT18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EMX2 grouped by Cytidine to uridine editing-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EMX2 →	-1.760	-1.866	<.001	<.001	3	4
LUNG_NSCLC_LUAD	GPSM1 →	-0.948	-0.987	.002	.002	3	4
BLOOD_Myeloma	NUDT18 →	-1.177	-1.878	.001	<.001	3	4
LIVER	PPP1R15A →	+1.281	+1.331	.004	.003	3	4
OVARY	TEX30 →	+0.863	+1.418	.007	<.001	3	4
BREAST	DSE →	+1.526	+1.133	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EMX2 by Cytidine to uridine editing activity — URINARY_TRACT

Explore this box plot interactively →