Base conversion or substitution editing

Across TCGA cell cohorts, RNA activity of the Base conversion or substitution editing pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMAN2L, DNAI4, and C14orf93, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Base conversion or substitution editing activity versus LMAN2L in LARGE_INTESTINE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LMAN2L →	+0.868	+0.253	.001	.002	3	2
LARGE_INTESTINE	DNAI4 →	+1.035	+0.244	.001	.001	3	2
LARGE_INTESTINE	C14orf93 →	-0.839	-0.322	.007	.004	3	1
LARGE_INTESTINE	TAF7L →	+0.537	+0.320	.008	.002	3	1
LARGE_INTESTINE	INTS10 →	+0.992	+0.320	.003	.002	3	1
LARGE_INTESTINE	C19orf53 →	+0.537	+0.256	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016553 vs LMAN2L — LARGE_INTESTINE

Explore this scatter interactively →