Base conversion or substitution editing

Across TCGA cell cohorts, RNA activity of the Base conversion or substitution editing pathway is significantly associated with the drug response of multiple features, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are RO-3306, CP466722, and Obatoclax Mesylate, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RO-3306 grouped by Base conversion or substitution editing-low versus -high activity in LARGE_INTESTINE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RO-3306 →	+0.688	+0.200	.018	.015	3	3
LARGE_INTESTINE	CP466722 →	+0.785	+0.243	.004	.006	3	3
BLOOD_Leukemia	Obatoclax Mesylate →	+0.663	+0.357	.031	.037	3	2
LARGE_INTESTINE	GSK1904529A →	+0.770	+0.300	.003	.029	3	2
BLOOD_Leukemia	Topotecan →	+0.745	+0.500	.012	.036	3	2
BLOOD_Leukemia	Elephantin →	+0.456	+0.357	.011	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RO-3306 by Base conversion or substitution editing activity — LARGE_INTESTINE

Explore this box plot interactively →