Protein autoprocessing

Across TCGA patient cohorts, RNA activity of the Protein autoprocessing pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUB1, PBLD, and FERMT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein autoprocessing activity versus SUB1 in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUB1 →	+0.256	+0.045	.008	.003	2	6
PDAC	PBLD →	+0.473	+0.034	.001	.005	3	5
COAD	FERMT2 →	-0.341	-0.022	.004	.001	3	5
LSCC	RPS6 →	+0.273	+0.050	.003	.001	3	4
OV	WRAP53 →	-0.585	-0.055	.002	.005	3	4
LSCC	MAP1LC3A →	-0.433	-0.032	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016540 vs SUB1 — LSCC

Explore this scatter interactively →