Protein autoprocessing

Across TCGA patient cohorts, RNA activity of the Protein autoprocessing pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP31, TNFSF15, and LINC02766, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein autoprocessing activity versus ARHGAP31 in UCEC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP31 →	-0.436	-0.137	<.001	.001	3	4
GBM	TNFSF15 →	+0.517	+0.231	.002	<.001	3	4
LSCC	LINC02766 →	-0.410	-0.180	<.001	<.001	3	4
LSCC	ERP29 →	+0.415	+0.155	<.001	.001	3	4
CCRCC	SEMA3F-AS1 →	-0.301	-0.236	<.001	<.001	3	4
HNSC	C16orf95 →	+0.483	+0.203	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016540 vs ARHGAP31 — UCEC

Explore this scatter interactively →