Cytosolic transport

Across TCGA patient cohorts, RNA activity of the Cytosolic transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, PALM, and PRKG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytosolic transport activity versus SEPTIN4_S432 in PDAC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEPTIN4_S432 →	+0.757	+0.034	<.001	<.001	3	7
COAD	PALM →	+0.391	+0.021	.002	<.001	3	7
BRCA	PRKG1 →	+0.536	+0.031	<.001	<.001	3	7
BRCA	RPL5 →	-0.213	-0.031	<.001	<.001	3	7
BRCA	MAP1A →	+0.356	+0.026	<.001	<.001	3	7
COAD	SERBP1 →	-0.167	-0.018	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016482 vs SEPTIN4_S432 — PDAC

Explore this scatter interactively →