Cytosolic transport

Across TCGA cell cohorts, RNA activity of the Cytosolic transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDX5, BCL2L13, and MRPS30, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytosolic transport activity versus PRDX5 in BONE (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PRDX5 →	+0.795	+0.355	.007	.001	3	5
LARGE_INTESTINE	BCL2L13 →	+0.414	+0.090	.005	.003	3	4
UPPER_AERODIGESTIVE_TRACT	MRPS30 →	-1.095	-0.122	<.001	.005	3	4
STOMACH	ALS2CL →	-2.622	-0.204	.004	.001	3	4
URINARY_TRACT	FAM3C →	-1.487	-0.190	.003	.007	3	3
OESOPHAGUS	ZNF671 →	+0.524	+0.144	.006	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016482 vs PRDX5 — BONE

Explore this scatter interactively →