Negative regulation of transcription by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Negative regulation of transcription by RNA polymerase I pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ING4, PRUNE1, and SART3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transcription by RNA polymerase I activity versus ING4 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ING4 →	+0.400	+0.041	<.001	.001	3	6
LSCC	PRUNE1 →	+0.359	+0.040	<.001	<.001	3	6
HNSC	SART3 →	+0.199	+0.064	<.001	<.001	3	6
LSCC	TRRAP →	+0.180	+0.034	<.001	<.001	3	5
LSCC	XPO1 →	+0.191	+0.038	<.001	<.001	3	5
LSCC	RBBP5 →	+0.214	+0.035	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016479 vs ING4 — LSCC

Explore this scatter interactively →