Negative regulation of transcription by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Negative regulation of transcription by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, COL5A1, and ITGA11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transcription by RNA polymerase I activity versus ACTA2 in OV (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACTA2 →	+1.428	+0.610	<.001	<.001	3	8
OV	COL5A1 →	+1.370	+0.709	<.001	<.001	3	8
OV	ITGA11 →	+1.170	+0.753	<.001	<.001	3	8
CCRCC	DACT1 →	+1.013	+1.295	<.001	<.001	3	8
CCRCC	TAGLN →	+1.291	+1.026	<.001	<.001	3	7
BRCA	ANTXR1 →	+1.115	+0.795	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016479 vs ACTA2 — OV

Explore this scatter interactively →