Negative regulation of transcription by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Negative regulation of transcription by RNA polymerase I pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FLNA_S1630, FLNA_S1976, and FLNA_S2414, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transcription by RNA polymerase I activity versus FLNA_S1630 in OV (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FLNA_S1630 →	+0.935	+0.794	<.001	<.001	3	8
BRCA	FLNA_S1976 →	+1.390	+1.104	<.001	<.001	3	7
OV	FLNA_S2414 →	+0.775	+0.707	<.001	<.001	3	7
OV	TLN1_S2162 →	+0.835	+0.558	<.001	<.001	3	7
GBM	SERPINH1 →	+0.541	+0.877	<.001	<.001	3	6
CCRCC	TAGLN →	+1.060	+0.956	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016479 vs FLNA_S1630 — OV

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