Negative regulation of transcription by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Negative regulation of transcription by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NNT, ANTXR1, and ZNF587B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NNT grouped by Negative regulation of transcription by RNA polymerase I-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NNT →	-1.829	-0.275	.007	.001	3	5
SKIN	ANTXR1 →	-0.815	-0.184	.003	.007	3	4
BONE	ZNF587B →	+0.934	+0.195	.005	.007	2	5
BLOOD_Myeloma	SAR1A →	-0.802	-0.202	.004	.004	3	4
STOMACH	WTIP →	-2.586	-0.242	<.001	.008	3	4
LUNG_NSCLC_LUAD	PSMA3 →	-0.518	-0.167	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NNT by Negative regulation of transcription by RNA polymerase I activity — PANCREAS

Explore this box plot interactively →