Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

Across TCGA patient cohorts, RNA activity of the Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, CTHRC1, and PCOLCE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules activity versus C1R in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1R →	+0.584	+0.055	.001	<.001	3	6
PDAC	CTHRC1 →	+0.726	+0.048	<.001	<.001	3	6
LSCC	PCOLCE →	+0.635	+0.038	<.001	.005	3	6
PDAC	SHTN1 →	-0.288	-0.031	<.001	<.001	3	6
PDAC	C9 →	+0.612	+0.036	<.001	<.001	3	6
PDAC	PROS1 →	+0.390	+0.030	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016339 vs C1R — OV

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