Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

Across TCGA patient cohorts, RNA activity of the Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BOK, AJUBA, and PGF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules activity versus BOK in PDAC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BOK →	+0.348	+0.227	<.001	<.001	3	5
BRCA	AJUBA →	+0.828	+0.707	.001	.003	2	5
BRCA	PGF →	+0.343	+0.605	.006	<.001	3	4
BRCA	SERPINH1 →	+0.826	+0.713	.001	.005	3	4
PDAC	CCNB1IP1 →	+0.197	+0.173	.003	.007	3	3
PDAC	HOXD9 →	+0.357	+0.211	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016339 vs BOK — PDAC

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