Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

Across TCGA cell cohorts, RNA activity of the Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1J, VAX2, and LRRC75B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPM1J grouped by Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PPM1J →	-1.198	-1.385	.001	.004	3	4
LUNG_NSCLC_LUSC	VAX2 →	-0.898	-1.372	.001	.007	3	4
LUNG_NSCLC_LUSC	LRRC75B →	-1.339	-1.626	<.001	.003	3	4
LUNG_NSCLC_LUSC	TMEM186 →	+0.744	+1.326	.001	.005	3	4
BLOOD_Lymphoma	CD83 →	+5.950	+2.048	.006	<.001	3	4
BONE	SPATA5 →	+0.532	+1.579	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPM1J by Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →