Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

Across TCGA patient cohorts, RNA activity of the Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS19, TMOD1, and HMGA1_S44, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules activity versus RPS19 in PDAC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPS19 →	-0.289	-0.055	.001	.004	3	5
PDAC	TMOD1 →	+0.536	+0.061	<.001	<.001	3	5
GBM	HMGA1_S44 →	-0.413	-0.068	.007	<.001	3	5
PDAC	CLIC5 →	+0.480	+0.064	.001	<.001	3	5
BRCA	COBL_S815 →	+0.638	+0.039	.008	.002	3	5
PDAC	FGD4 →	+0.284	+0.047	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016338 vs RPS19 — PDAC

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