Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

Across TCGA cell cohorts, RNA activity of the Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFB2M, MRPS35, and KAT6A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TFB2M grouped by Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TFB2M →	+0.879	+1.190	.001	.003	3	4
LUNG_NSCLC_LUAD	MRPS35 →	+0.615	+0.760	.001	.007	3	4
LIVER	KAT6A →	+1.126	+1.254	.001	.002	3	4
BLOOD_Leukemia	POLR1B →	+0.788	+1.197	.009	.008	2	5
BLOOD_Leukemia	RFX3 →	+0.876	+1.176	.009	.004	3	4
LUNG_NSCLC_LUSC	GPRC5B →	-2.774	-0.557	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TFB2M by Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules activity — BLOOD_Leukemia

Explore this box plot interactively →