Neuron remodeling

Across TCGA patient cohorts, RNA activity of the Neuron remodeling pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL11A, ANKS1A, and C20orf204, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron remodeling activity versus BCL11A in HNSC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BCL11A →	+0.813	+0.750	<.001	<.001	3	5
LSCC	ANKS1A →	+0.310	+0.741	.003	.001	3	5
UCEC	C20orf204 →	+0.424	+0.637	.008	.003	3	4
COAD	TXNP6 →	-0.565	-0.626	.006	<.001	3	4
HNSC	KDM2B →	+0.490	+0.664	.001	.006	3	4
HNSC	EZH1 →	+0.399	+0.775	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016322 vs BCL11A — HNSC

Explore this scatter interactively →