Neuron remodeling

Across TCGA cell cohorts, RNA activity of the Neuron remodeling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3, TNFSF14, and THYN1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron remodeling activity versus C3 in LIVER (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	C3 →	+6.044	+0.293	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	TNFSF14 →	+0.683	+0.207	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	THYN1 →	-0.965	-0.161	<.001	.003	3	10
UPPER_AERODIGESTIVE_TRACT	SNRPG →	-1.155	-0.203	<.001	<.001	3	8
OVARY	SLPI →	+3.822	+0.162	<.001	<.001	3	8
KIDNEY	SENP1 →	-0.875	-0.223	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016322 vs C3 — LIVER

Explore this scatter interactively →