Attachment of GPI anchor to protein

Across TCGA patient cohorts, RNA activity of the Attachment of GPI anchor to protein pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLKL, GIMAP8, and LINC01003, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of GPI anchor to protein activity versus MLKL in LSCC (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MLKL →	-0.547	-0.137	<.001	<.001	3	6
UCEC	GIMAP8 →	-0.690	-0.214	.004	<.001	3	6
GBM	LINC01003 →	+0.552	+0.121	.005	.009	3	6
LSCC	FOXRED2 →	+0.821	+0.215	<.001	<.001	3	5
LUAD	CDK5RAP1 →	+0.359	+0.138	<.001	<.001	3	5
LSCC	FMR1 →	+0.425	+0.136	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016255 vs MLKL — LSCC

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