Attachment of GPI anchor to protein

Across TCGA cell cohorts, RNA activity of the Attachment of GPI anchor to protein pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERGIC3, RPN2, and RBM39, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of GPI anchor to protein activity versus ERGIC3 in SOFT_TISSUE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ERGIC3 →	+0.955	+1.857	.001	.003	3	9
STOMACH	RPN2 →	+1.242	+2.046	<.001	<.001	3	8
OVARY	RBM39 →	+1.161	+1.584	<.001	.001	3	8
LUNG_SCLC	PPP1R3D →	+1.090	+1.305	.003	.004	3	6
LUNG_SCLC	CTSA →	+1.194	+1.546	.006	<.001	3	6
STOMACH	TTLL12 →	-1.011	-1.596	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016255 vs ERGIC3 — SOFT_TISSUE

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