Negative regulation of macroautophagy

Across TCGA patient cohorts, RNA activity of the Negative regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC12, RAP1AP, and RNU6-920P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macroautophagy activity versus H2AC12 in LSCC (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	H2AC12 →	-0.694	-0.534	<.001	<.001	3	5
UCEC	RAP1AP →	+0.930	+0.593	.004	.001	3	4
PDAC	RNU6-920P →	+0.646	+0.610	.009	.006	3	4
BRCA	CPSF4 →	-0.379	-0.319	.004	.005	3	4
CCRCC	ZNF775 →	-0.250	-0.573	.006	.003	3	4
CCRCC	UBE2SP1 →	-0.332	-0.689	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016242 vs H2AC12 — LSCC

Explore this scatter interactively →