Negative regulation of macroautophagy

Across TCGA cell cohorts, RNA activity of the Negative regulation of macroautophagy pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC1, MAGT1, and MPI, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC1 grouped by Negative regulation of macroautophagy-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DNAJC1 →	+0.241	+1.131	<.001	<.001	3	3
STOMACH	MAGT1 →	+0.354	+1.575	<.001	.002	3	3
SKIN	MPI →	-0.115	-1.238	.009	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	GNG13 →	-0.296	-0.450	.006	.008	3	3
UPPER_AERODIGESTIVE_TRACT	ADCK2 →	+0.204	+0.326	.002	.004	3	3
UPPER_AERODIGESTIVE_TRACT	RGS20 →	+0.223	+0.396	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC1 by Negative regulation of macroautophagy activity — CNS

Explore this box plot interactively →