Negative regulation of macroautophagy

Across TCGA cell cohorts, RNA activity of the Negative regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYPLA1, CDK16, and COX5B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macroautophagy activity versus LYPLA1 in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LYPLA1 →	+1.175	+1.222	.003	<.001	3	6
LIVER	CDK16 →	-0.932	-0.275	.003	.004	3	5
STOMACH	COX5B →	-0.964	-1.370	.007	.001	2	5
STOMACH	ZNF433 →	+1.749	+1.136	<.001	<.001	3	4
LUNG_SCLC	SGCB →	-1.160	-0.860	<.001	.001	3	4
LUNG_SCLC	ZNF563 →	+0.918	+1.161	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016242 vs LYPLA1 — BLOOD_Lymphoma

Explore this scatter interactively →