Regulation of macroautophagy

Across TCGA patient cohorts, RNA activity of the Regulation of macroautophagy pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, RPL5, and CNRIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macroautophagy activity versus SORBS1 in BRCA (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SORBS1 →	+0.645	+0.028	<.001	<.001	3	8
GBM	RPL5 →	-0.220	-0.047	.001	<.001	2	8
GBM	CNRIP1 →	+0.725	+0.057	<.001	<.001	3	7
BRCA	RPL10 →	-0.219	-0.021	.001	.001	3	7
GBM	SEPTIN4 →	+0.832	+0.059	<.001	<.001	3	7
GBM	ATAD2_S342 →	-0.974	-0.050	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016241 vs SORBS1 — BRCA

Explore this scatter interactively →