Regulation of macroautophagy

Across TCGA patient cohorts, RNA activity of the Regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL7P41, DESI2, and VASH2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macroautophagy activity versus RPL7P41 in COAD (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL7P41 →	+0.063	+0.119	.006	<.001	3	2
BRCA	DESI2 →	-1.008	-0.217	.008	.003	3	2
BRCA	VASH2 →	-1.354	-0.182	<.001	<.001	3	2
BRCA	MAOA →	+2.497	+0.218	.004	.007	3	2
BRCA	C9orf163 →	+0.908	+0.212	.003	.002	3	2
BRCA	SYS1 →	+1.181	+0.275	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016241 vs RPL7P41 — COAD

Explore this scatter interactively →