Regulation of macroautophagy

Across TCGA cell cohorts, RNA activity of the Regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM98, IQCH, and SPEG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM98 grouped by Regulation of macroautophagy-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMEM98 →	-2.156	-0.124	.001	.007	3	4
PANCREAS	IQCH →	-0.698	-0.132	.001	.008	3	4
BONE	SPEG →	-2.010	-0.232	.001	.003	2	5
SKIN	DCAF10 →	-0.764	-0.123	.001	.003	3	4
SKIN	ZNF474 →	-0.182	-0.156	.001	.001	3	4
CNS	MATN3 →	-1.018	-0.140	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM98 by Regulation of macroautophagy activity — OVARY

Explore this box plot interactively →