Regulation of macroautophagy

Across TCGA cell cohorts, RNA activity of the Regulation of macroautophagy pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIFM1, ANKRD39, and CDKN2D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macroautophagy activity versus AIFM1 in SOFT_TISSUE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AIFM1 →	+1.066	+0.147	<.001	.007	3	5
SKIN	ANKRD39 →	+1.203	+0.203	.007	.003	2	6
OESOPHAGUS	CDKN2D →	+1.208	+0.195	.003	.001	3	5
BLOOD_Lymphoma	IGF1R →	-1.385	-0.141	<.001	.002	3	5
LIVER	KDM5C →	+0.871	+0.181	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PCBD1 →	+1.059	+0.095	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016241 vs AIFM1 — SOFT_TISSUE

Explore this scatter interactively →