Autophagosome membrane docking

Across TCGA patient cohorts, RNA activity of the Autophagosome membrane docking pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT11, ZNRF2, and MIR450B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome membrane docking activity versus WNT11 in PDAC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	WNT11 →	-1.325	-0.178	.002	.003	3	4
BRCA	ZNRF2 →	+0.568	+0.254	.003	<.001	3	3
OV	MIR450B →	-0.374	-0.173	.001	.004	3	3
OV	NIFK-AS1 →	-0.451	-0.128	.004	.009	2	4
BRCA	GALE →	+0.487	+0.136	.009	.004	3	3
BRCA	MAP3K21 →	-0.528	-0.121	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016240 vs WNT11 — PDAC

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